Macrophages are highly plastic, and functionally diverse cells that play key roles during the processes of tissue repair. While required for proper muscle regeneration following […]
Duchenne muscular dystrophy (DMD) is a fatal disease resulting from the absence of dystrophin that causes chronic striated muscle injury and gradual muscle degeneration, leading […]
The standard-of-care for Duchenne Muscular Dystrophy (DMD) patients is glucocorticoid treatment, which improves skeletal muscle pathology in part by dampening chronic inflammation. Despite decades of […]
Antisense oligonucleotide-induced (ASO) exon skipping is a promising treatment strategy for Duchenne muscular dystrophy (DMD), an X-linked fatal neuromuscular disease caused by mutations in the […]
Background The primary causes of the reduced life span of patients with Duchenne Muscular Dystrophy (DMD) are severe respiratory insufficiency, due to the weakening of […]
Duchenne muscular dystrophy (DMD) is a rare and fatal disease with no cure. Cardiomyopathy (CM) is the leading cause of death. Thromboxane prostanoid receptor (TPr) […]
Exon skipping therapeutic oligonucleotides are precision medicines designed to modulate the genetic machinery, which show great promise in treating genetic disorders such as Duchenne muscular […]
Many therapies, current and envisioned, for DMD produce edited dystrophins. Most of these edits occur in the STR region which forms the bulk of this […]
Muscle stem cells, first characterized by Satellos founder Dr. Michael Rudnicki , represent a subpopulation of satellite cells located in a specialized niche beneath the […]