Striated muscle needs to adapt its cellular homeostasis to frequent changes in physiological and metabolic demands. Failure to do so can result in loss of […]
Background: Prodromal biomarkers heralding symptom conversion are under investigation for people with ALS. Indicators of axonal degeneration, such as neurofilament, may elevated prior to symptom […]
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease where muscle weakness and neuromuscular junction (NMJ) denervation precedes motor neuron cell death. Although acetylcholine is […]
Duchenne muscular dystrophy (DMD) is a progressive X-linked neuromuscular disease where patients develop severe muscle weakness, cardiomyopathy, and respiratory failure. Interestingly, many common pathological symptoms […]
BACKGROUND: One of the hallmarks of injured skeletal muscle is the appearance of elevated skeletal muscle proteins in circulation. Human skeletal muscle generally consists of a mosaic of slow […]
Background: Limb-girdle muscular dystrophy type 2B (LGMD2B) is caused by mutations in the dysferlin gene, resulting in non-functional dysferlin, a key protein found in muscle […]
Limb-girdle muscular dystrophy 2B (LGMD2B) stems from heterogenous mutations in dysf. Dysferlin is a critical muscle membrane protein and is associated with sarcolemma repair. Reduced […]
Background: Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease hallmarked by rapid loss of upper and lower motor neurons. The vast […]
Muscular dystrophies are a heterogeneous group of genetic diseases involving mutations in genes that compromise sarcolemma stability, muscle strength, and repair. Limb-girdle muscular dystrophy type […]