N6-methyladenosine (m6A) is a highly conserved posttranscriptional modification essential for gene expression, cellular function, and the determination of stem cell fates. As a result, it is regulated via a diversity of mechanisms and continues to be a promising field for study. m6A RNA methylation is mediated by multiple classes of proteins, known as writers, erasers, and readers, which are in turn controlled by various transcription factors and regulatory pathways. Dysregulation of these fundamental processes is implicated in a wide range of diseases and disorders, exemplifying their importance in guiding normal physiological activity. In this review, we focused on the effects of m6A modification on muscle stem cells (MuSCs) in particular, a critical component of skeletal muscle development and regeneration. Further, we evaluated contemporary literature and expert perspectives to outline the mechanisms of m6A RNA methylation, emphasizing their role in MuSCs and their potential for the development of novel therapeutic strategies.